Publications

Schatton T, Itoh Y, Martins C, Rasbach E, Singh P, Silva M, Mucciarone K, Heppt MV, Geddes-Sweeney J, Stewart K, Brandenburg A, Liang J, Dimitroff CJ, Mihm Jr. MC, Landsberg J, Schlapbach C, Lian CG, Murphy GF, Kupper TS, Ramsey MR, and Barthel SR.  Inhibition of melanoma cell-intrinsic Tim-3 stimulates MAPK-dependent tumorigenesis. Cancer Research, In Press

Boudra R, Woappi Y, Wang D, Shuyun Xu S, Wells M, Schmults CD, Lian CG, Ramsey MR. Regulation of 5-hydroxymethylcytosine by TET2 contributes to Squamous Cell Carcinoma tumorigenesis, J Invest Dermatol. 2022 May;142(5):1270-1279. [pdf]

Sato K, Parag-Sharma K, Terajima M, Musicant AM, Murphy RM, Ramsey MR, Hibi H, Yamauchi M, Amelio AL. Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas. Neoplasia. 2021 Jun;23(6):594-606. [pdf]

Boudra R and Ramsey MR. Understanding Transcriptional Networks Regulating Initiation of Cutaneous Wound Healing. Yale J Biol Med, 2020 Mar;93(1). [pdf]

Li F, Yuan CW, Xu S, Zu T, Woappi Y, Lee CAA, Abarzua P, Wells M, Ramsey MR, Frank NY, Wu X, Mandinova A, Frank MH, Lian CG, Murphy GF.  Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation.  J. Invest. Dermatol. 2020 Jun;140(6):1266-1275.[pdf]

Cuevas-Nunez MC, Gomes CBF, Woo SB, Ramsey MR, Chen XL, Xu S, Xu T, Zhan Q, Murphy GF, Lian CG. Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jan;125(1):59-73. [pdf]

Best SA, Nwaobasi AN, Schmults CD, and Ramsey MR. CCAR2 is required for proliferation and tumor maintenance in human Squamous Cell Carcinoma. J. Invest. Dermatol. 2017 Feb;137(2): 506-512. [pdf]

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Ramsey MR, Wilson C, Ory B, Rothenberg SM, Faquin WC, Mills AA, and Ellisen LW. FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma. J. Clin. Invest. 2013 123: 3525-3538. [pdf]

Gallant-Bhem C, Ramsey MR, Bensard C, Nojek I, Tran J, Liu M, Ellisen LW, and Espinosa JM. ΔNp63α represses anti-proliferative genes via H2A.Z deposition. Genes Dev. 2012 26: 2325-2336. [pdf]

Ramsey MR, Ellisen LW. Circadian function in cancer: Regulating the DNA damage response. Proc Natl Acad Sci U S A 2011 108: 10379-80. [pdf]

Ramsey MR, He L, Forster N, Ory B, and Ellisen LW. Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. Cancer Res. 2011 71: 4373-9. [pdf]

Ory B, Ramsey MR, Wilson C, Vadysirisack DD, Forster N, Rocco JW, Rothenberg SM, and Ellisen LW. A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma. J. Clin. Invest. 2011 121: 809-820. [pdf]

Johnson SM, Torrice CD, Bell JF, Monahan KB, Jiang Q, Wang Y, Ramsey MR, Jin J, Wong KK, Su L, Zhou D and Sharpless NE. Inhibition of Cdk4/6 induces pharmacologic quiescence and mitigation of hematologic radiation toxicity in mice. J. Clin. Invest. 2010 120: 2528-36. [pdf]

Harvey KF, Mattila J, Sofer A, Bennett FC, Ramsey MR, Ellisen LW, Puig O, and Hariharan IK. FOXO-regulated transcription restricts overgrowth of Tsc mutant organs. J. Cell Biol. 2008 180: 691-696. [pdf]

Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera S, Liang MC, Cai D, Naumov GN, Bao L, Contreras C, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera R, Bronson RT, Lindeman N, Christiani DC, Lin X, Shapiro GI, Jänne PA, Johnson B, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, and Wong KK. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007 448: 807-810. [pdf]

Ramsey MR, Krishnamurthy J, Pei XH, Torrice C, Lin W, Carrasco DR, Ligon K, Toogood P, Xiong Y, and Sharpless NE. Expression of p16Ink4a compensates for p18Ink4c loss in cdk4/6 dependent tumors and tissues. Cancer Res. 2007 67: 4732-4741. [pdf]

Ramsey MR and Sharpless NE. ROS as a tumor suppressor? Nat. Cell Biol. 2006 8(11): 1213 – 1215. [pdf]

Krishnamurthy J, Ramsey MR, Ligon K, Torrice C, Bonner-Weir S, Sharpless NE. p16Ink4a induces an age-dependent decline in islet regenerative potential. Nature 2006 443: 453-457. [pdf]

Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, and Sharpless NE. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 2004 114: 1299-1307. [pdf]

Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, and DePinho RA. The differential impact of p16Ink4a or p19Arf deficiency on cell growth and tumorigenesis. Oncogene 2004 23(2): 379-385. [pdf]

Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricala C, O’Toole KM. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol. Cell Biol. 2002 22(14):5157-72. [pdf]

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